T7 High-Capping RNA Polymerase (200 U/μl)-DD4122-PB

 Product Description  

T7 High-Capping RNA Polymerase is a recombinant T7-derived variant expressed in E. coli. This DNA-dependent 5′→3′RNA polymerase selectively recognizes T7 promoter sequences and transcribes RNA from ssDNA or dsDNA templates using NTPs. Engineered for enhanced co-transcriptional cap incorporation, it provides substantially higher mRNA capping efficiency than wild-type T7 RNAP—enabling reduced cap-analog input and improved downstream translation. Suited for IVT workflows that demand high cap fidelity, scalability, and cost-efficient mRNA production.

 Features  

• Dramatically reduce the cost of capping by increasing the Kd_Cap/Kd_NTP, either through

- Reducing the Cap analog input by 95%, or 

- Utilizing wild type T7 promoter (GG)

• Comparable CQA to T7 WT

• Tested and confirmed across various mRNA sequences

 Performance